影响药物反应的关键因素
1. Physiological Determinants Age-Related Variations: Sex Differences: 2. Pathological Considerations Hepatic Impairment: Renal Dysfunction: 3. Genetic Polymorphisms Clinically Significant Pharmacogenomic Markers: 4. Drug-Drug Interactions Mechanistic Classification: Interaction Type Prototypical Example Clinical Consequence Pharmacodynamic synergy Warfarin + SSRIs 3-fold bleeding risk increase CYP3A4 inhibition Clarithromycin + statins Rhabdomyolysis incidence 5× higher P-glycoprotein induction Rifampin + digoxin…